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Klotho Inhibits EGF-induced Cell Migration in Caki-1 Cells

Klotho is a transmembrane protein that has been reported to have anti-cancer properties. In this study, researchers analyze the effects of Klotho on EGF-mediated cell migration in Caki-1 cells. Caki-1 cells were treated in vitro with Klotho and cell adhesion, migration, and biochemical studies were conducted to observe the effects. Results showed that Klotho successfully inhibited EGF-induced Caki-1 adhesion, and migration through the inactivation of EGFR and p38 MAPK signaling pathways. These findings suggest that cRCC metastasis could be a result of decreased Klotho expression. [LINK] 

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